DRDO invitations EoI to switch expertise of 2-DG drug for bulk manufacturing | The Chhattisgarh

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June 24, 2021

The Chhattisgarh

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DRDO invitations EoI to switch expertise of 2-DG drug for bulk manufacturing

The Defence Analysis and Improvement Organisation (DRDO), which developed 2-Deoxy-D-Glucose (2-DG), a drug used for remedy of COVID-19 sufferers, has referred to as for Expression of Curiosity (EoI) to switch the expertise to Indian pharmaceutical industries for manufacturing.
2-DG was developed by the Institute of Nuclear Medication and Allied Sciences (INMAS), a lab of DRDO, in collaboration with Dr Reddy’s Laboratories.
Medical trial outcomes have proven that this molecule helps in sooner restoration of hospitalised sufferers and reduces supplemental oxygen dependence.
Greater proportion of sufferers handled with 2-DG confirmed RT-PCR adverse conversion in COVID sufferers.
In line with the EoI doc, functions ought to be submitted earlier than June 17 by electronic mail.
“The EoI submitted by industries might be scrutinised by a Technical Evaluation Committee (TAC).
Solely as much as 15 industries might be given ToT on their capabilities, technical hand holding functionality of DRDO and on First Come First Served Foundation,” it stated.
The bidders ought to have a Drug license to fabricate Lively Pharmaceutical Ingredient (API) from Drug Licensing Authorities and WHO GMP (Good manufacturing Practices) certification amongst others.
Laboratory synthesis course of for 2-DG has been developed utilizing D-Glucose as beginning materials.
The synthesis course of consists of conversion of D-Glucose to 2-DG by 5 chemical response steps adopted by purification.
The method has been established at batch scale (100g) and pilot plant scale (500g) and obligatory patents have been filed by DRDO on this regard, the Defence physique stated.

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