Taking oxycodone similtaneously sure selective serotonin reuptake inhibitors (SSRIs), a generally prescribed class of antidepressant, can enhance the chance of opioid overdose, in line with a research my colleagues and I printed.
Medical doctors prescribe the opioid oxycodone to deal with average to extreme ache after surgical procedures and accidents or sure situations like most cancers. Opioids are additionally a standard drug of abuse. Within the U., over 70 per cent of drug overdose deaths in 2019 concerned an opioid.
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As a result of many sufferers with melancholy additionally expertise continual ache, opioids are sometimes coprescribed with antidepressants like SSRIs.
Prior analysis has proven that sure SSRIs, particularly fluoxetine (Prozac or Sarafem) and paroxetine (Paxil, Pexeva or Brisdelle), can strongly inhibit a liver enzyme essential to the correct breakdown of medicine within the physique, together with oxycodone.
The ensuing elevated focus of oxycodone within the blood could result in unintentional overdose.
Additional investigation of how different medication work together with opioids might assist medical doctors (Consultant Picture/ Getty Photos/ Thinkstock)
To see whether or not various kinds of SSRIs would possibly have an effect on a affected person’s threat of overdosing on oxycodone, my colleagues and I examined knowledge from three massive US medical insurance claims databases. We included over 2 million adults who started taking oxycodone whereas utilizing SSRIs between 2000 and 2020. The typical age of the group was round 50, and a little bit over 72 per cent have been girls. A bit over 30 per cent have been taking the SSRIs paroxetine and fluoxetine.
We discovered that sufferers taking paroxetine or fluoxetine had a 23 per cent increased threat of overdosing on oxycodone than these utilizing different SSRIs.
About 30 per cent of sufferers with continual ache expertise antagonistic drug interactions whereas taking opioids. Different varieties of medication have been proven to extend the chance of overdose and different dangerous interactions.
These embody some muscle relaxants generally used to deal with ache, benzodiazepines generally used to deal with nervousness or poor sleep and a few antipsychotics generally used to deal with schizophrenia or bipolar dysfunction.
Equally, in 2019, the Meals and Drug Administration required drugmakers to incorporate new warnings on utilizing gabapentinoids, a category of medicine generally used to deal with epilepsy and ache, concurrently with opioids and different medication that suppress the central nervous system. This mandate was because of an elevated threat of dangerously diminished respiration charges that can lead to overdose and dying when these medication are taken collectively.
The findings from our research supply perception on which of essentially the most generally used antidepressants might most probably result in opioid overdose. Additional investigation of how different medication work together with opioids might assist medical doctors and sufferers higher perceive which medication are protected to take on the similar time.
The creator is Assistant Professor of Scientific Pharmacy and Outcomes Sciences, College of South Carolina South Carolina
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