Revolutionary work by Chinese scientists reveals how a specific Ebola mutation amplified infections during the prolonged DRC crisis of 2018-2020. The Cell-published study analyzed genomic shifts that turned the tide against containment.
With over 3,000 cases and 2,000+ fatalities, the epidemic exposed vulnerabilities. Sun Yat-sen University’s Professor Qian Jun’s team sequenced 480 genomes to uncover the culprit: GP-V75A in the viral glycoprotein.
Emerging early, this mutation swiftly replaced the dominant strain, aligning perfectly with escalating transmissions. ‘Such changes are invisible drivers of outbreaks,’ noted Prof. Jun after years of study.
Rigorous tests confirmed boosted infection in diverse cells and rodents. Critically, it weakened several antiviral antibodies and inhibitors, signaling emerging drug resistance.
The implications are profound: relentless genomic vigilance during outbreaks can preempt dangers, optimize interventions, and fortify defenses. This advances our arsenal against hemorrhagic fevers worldwide.